Aztreonam (azthreonam; SQ 26,776) is the first member of a new class of beta-lactam antibiotics, the monobactams. Aztreonam is selectively active against Gram-negative aerobic bacteria and inactive against Gram-positive bacteria.
Is aztreonam a penicillin?
Monobactams. Aztreonam is a monocyclic β-lactam (monobactam) lacking the thiazolidine ring of penicillin (see Fig. 33-7). It is available only parenterally.
Is aztreonam a broad spectrum antibiotic?
Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes, but has very broad spectrum against gram-negative aerobes, including Pseudomonas aeruginosa.
Is aztreonam bactericidal or bacteriostatic?
Aztreonam is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Aztreonam has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
Is aztreonam an anti infective drug?
Aztreonam is a novel antimicrobial agent belonging to the monobactam class of antibiotics. It inhibits both beta-lactamase-producing and non-beta-lactamase-producing aerobic gram-negative bacilli, but it has no activity against gram-positive species or against anaerobic species.
What bugs does aztreonam cover?
It is known to be effective against a wide range of bacteria including Citrobacter, Enterobacter, E. coli, Haemophilus, Klebsiella, Proteus, and Serratia species.
Is aztreonam cross allergenic with penicillin?
Aztreonam is a monobactam antibiotic that contains a betalactam ring. However, unlike other beta-lactam antibiotics, aztreonam does not contain a bicyclic-ring structure (6). To date, aztreonam has not demonstrated clinical cross-reactivity in penicillin-allergic patients (2, 8).
Is azactam good for UTI?
AZACTAM is indicated for the treatment of the following infections caused by susceptible Gram-negative microorganisms: Reference ID: 3326494 Page 10 10 Urinary Tract Infections (complicated and uncomplicated), including pyelonephritis and cystitis (initial and recurrent) caused by Escherichia coli, Klebsiella.
Is Monobactam broad spectrum?
Monobactams are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases.
When should I take aztreonam?
Aztreonam is usually given as long as needed until your infection has cleared, or until you have been symptom-free for at least 48 hours. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
What are the contraindications of aztreonam?
Contraindications / Precautions General Information. Viral infection. Carbapenem hypersensitivity, cephalosporin hypersensitivity, penicillin hypersensitivity. Renal disease, renal failure, renal impairment. Colitis, diarrhea, GI disease, inflammatory bowel disease, pseudomembranous colitis, ulcerative colitis.
Is ceftazidime a penicillin?
Ceftazidime is a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic that is bactericidal through inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin-binding protein 3 (PBP3).
Does azactam contain penicillin?
Aztreonam is a monobactam antibiotic that was approved in 1986 for the treatment of Gram-negative bacterial infections via intravenous or intramuscular injection (Azactam®) [20]. This drug was marketed to treat bacterial infections and is safe for patients with penicillin allergies [21].
What can aztreonam treat?
Aztreonam injection is used to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary tract, blood, skin, gynecological, and abdominal (stomach area) infections, that are caused by bacteria.
Does aztreonam cover MRSA?
MRSA infections are staphylococcal infections that are resistant to beta-lactam antibiotics including: penicillin, ampicillin, amoxicillin, amoxicillin/clavulanate, methicillin, oxacillin, dicloxacillin, nafcillin, cephalosporins, carbapenems (e.g., imipenem), and the monobactams (e.g., aztreonam).
What type of antibiotic is ceftriaxone?
Ceftriaxone is a cephalosporin (SEF a low spor in) antibiotic. Ceftriaxone is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis.
Is ceftazidime Avibactam an antibiotic?
Ceftazidime is a cephalosporin antibiotic that works by stopping the growth of bacteria. Avibactam is an enzyme inhibitor (beta-lactamase inhibitor) that helps ceftazidime work better.
What bugs does Ancef cover?
Staphylococcus epidermidis. Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae and other strains of streptococci.
What kind of bacteria does bactrim treat?
Bactrim (sulfamethoxazole and trimethoprim) DS is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, Shigellosis, Pneumocystis pneumonia, traveler’s diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections susceptible to this.
What antibiotics should be avoided with penicillin allergy?
It is generally recommended that you avoid all drugs in the immediate penicillin family (amoxicillin, ampicillin, amoxicillin-clavulanate, dicloxacillin, nafcillin, piperacillin-tazobactam as well as certain drugs in the cephalosporin class (a closely related class to penicillins).
What do you give someone who is allergic to penicillin?
Tetracyclines (e.g. doxycycline), quinolones (e.g. ciprofloxacin), macrolides (e.g. clarithromycin), aminoglycosides (e.g. gentamicin) and glycopeptides (e.g. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient.
Which cephalosporins can be used with penicillin allergy?
Cephalothin, cephalexin, cefadroxil, and cefazolin confer an increased risk of allergic reaction among patients with penicillin allergy. Cefprozil, cefuroxime, cefpodoxime, ceftazidime, and ceftriaxone do not increase risk of an allergic reaction.
How long should you use aztreonam?
The duration of therapy depends on the severity of infection. Generally, AZACTAM should be continued for at least 48 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. Persistent infections may require treatment for several weeks.
What is another name for aztreonam?
BRAND NAME(S): Azactam. USES: Aztreonam is used to treat a wide variety of bacterial infections. This medication is an antibiotic that works by stopping the growth of bacteria.
What class of antibiotic is imipenem?
Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors.
What type of antibiotic is Monobactam?
Monobactams are monocyclic and bacterially-produced β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams. Monobactams are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas).
Are Monobactams broad or narrow spectrum?
Monobactam agents have a narrow and characteristic spectrum of activity. They work only against Gram-negative bacilli, including Pseudomonas aeruginosa, and are not active against Gram-positive bacteria and anaerobes.
Is streptomycin an antifungal?
A drug used to treat or prevent microbial infections. Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties. Any antifungal agent used to prevent or treat fungal infections in humans or animals.CHEBI:17076 – streptomycin. ChEBI Name streptomycin ChEBI ID CHEBI:17076.